(Voet & Voet Chapter 17)
2). Where does the glycogen exist in the body and its physiological function at those organs?
3). Why the body has to use glycogen? Can fat be used instead of glycogen?
b. What is the role of pyridoxal-5-phosphate (PLP) in phosphorylase and its functional difference in amino acid metabolism (e.g. transamination)?
c. What is the reaction intermediate of the phosphoglucomutase reaction?
d. What kind of reaction(s) is/are
catalyzed by glycogen debranching enzyme?
b. What is the ¡§primer¡¨ for glycogen synthesis?
c. What is the functional difference between glycogen debranching and branching enzymes? And its thermodynamic consideration?
7). What are the mechanism differences between the £\-adrenergic and £]-adrenergic functions of the hormonal (e.g. epinephrine) action on glycogen metabolism?
8). What are the roles of phospolipase C and adenylate cyclase in hormonal actions? What kind of second messenger(s) are generated by these enzymes and how do they function?
9). What is the significance of the (1) covalent modification of enzymes and (2) enzyme cascades compare to other regulatory mechanisms?
10). How does Ca++ modulate
the glycogen metabolism (function of Calmodulin)?
Last modified on 2000.12.21 by K.-J. Hsiao (¿½¼s¤¯) [ º¶ ]