1999.3.9

Gluconeogenesis

(Voet & Voet Chapter 21)


1). Noncarbohydrate precursors and lactate/pyruvate can be converted into glucose via oxaloacetate (OAA). Could animals convert acetyl-CoA into glucose? Why?

2). Biotin and carboxylation mechanism.

3). How is the OAA transported from mitochrondria to cytosol for gluconeogenesis?

4). Where are the control points (enzymes) of gluconeogenesis? How is it regulated?

5). Compare to glycolysis, how many high energy bonds (ATP) are needed for gluconeogenesis from pyruvate?

6). Cori cycle and futile cycle (Liver=>gluconeogenesis : Muscle=>glycolysis)

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Practice Problem : Question 1 of Chapter 21 (Veot & Veot, p. 625)
 


Glyoxylate Cycle
(Voet & Voet Chapter 21)
1). Two acetyl-CoA are converted to one OAA, two NADH, and one FADH2 via glyoxylate cycle.

2). Where does glyoxylate cycle take place in what kind of living organism? Why?


Last modified on 2000.12.21 by K.-J. Hsiao (s)                          [ ]